The Use of Recent Advances in Electron Microscopy To Study Ribosome Structure
by Nobel Prize Winner Prof. Venki Ramakrishnan
Date: 7th January 2016
Time: 03:00 PM
Venue: JNU Convention Centre, Jawaharlal Nehru University, New Delhi, India
The Rutherford Memorial Lecture of the Royal Society, named in honor of Ernest Rutherford FRS and first delivered in 1952, is an annual exchange lecture between university centres in the Commonwealth. One in three is given in New Zealand.
For the last hundred years, the main technique to determine the atomic structures of molecules has been X-ray crystallography. Recently, advances in both detectors and algorithms for data analysis has made it possible to reach ~3A resolution for biological macro-molecules using single-particle electron microscopy. This has for the first time made it possible to obtain atomic models of these molecules without the use of crystals and with very small amounts and heterogeneous samples. I will discuss how my laboratory has used these advances to determine an atomic model for the mitochondrial ribosome de novo.
RSVP: Dr B Chandrasekar <firstname.lastname@example.org>, Ph: +91-9899753575